• Study Guide

Middlesex is Jeffrey Eugenides' Pulitzer-winning novel about Cal, the intersex protagonist who uncovers a guilty family secret and an astonishing genetic history as he comes of age. ,Explore a character analysis of Cal/Calliope, plot summary, and important quotes.


See a complete list of the characters in Middlesex and in-depth analyses of Cal/Calliope Stephanides, Desdemona Stephanides, Eleutherios “Lefty” Stephanides, and Milton Stephanides.

Main Ideas

Here's where you'll find analysis about the book as a whole.


Find the quotes you need to support your essay, or refresh your memory of the book by reading these key quotes.

Further Study

Continue your study of Middlesex with these useful links.

Teacher's Handbook

Teachers, check out our ideas for how you can creatively incorporate SparkNotes materials into your classroom instruction.


Go to BN.com to get your copy of these helpful resources.