1452: ·Leonardo born on April 15, in Vinci. Leonardo was born to Ser Piero, a notary, and Caterina, a peasant girl; his parents were never married.
1467: ·Leonardo becomes an apprentice to Andrea del Verrocchio, in Florence. This date is an estimate, the apprenticeship could have begun a year or two later. But even 1467 would have been a bit late according to the customs of the time: Leonardo would have been fifteen, and most apprentices began at a younger age.
1469: ·Lorenzo and Giuliano de Medici become new rulers of Florence. The two brothers took over when their father died. 1469 also marks the birth of Machiavelli, who would be an important advisor to Lorenzo and later write the work of political philosophy entitled The Prince (1515).
1472: ·Leonardo becomes a member of the Florence painters' guild. Birth of Copernicus. Dante's The Divine Comedy is published. Other famous painters to join the painters' guild in 1472 were Botticelli and Perugino.
1473: ·Leonardo draws a landscape on the Feast of Santa Maria delle Neve. This is his earliest known drawing, though he probably also had a hand in Verrochio's Baptism of Christ, which probably reached completion in or around 1473.
1475: ·Michelangelo born
1476: ·Leonardo charged with sodomy on April 9; the case is dismissed June 16.
1477: ·Leonardo had at least some part in the painting the Annunciation to the Virgin, completed around this time.
1478: ·The Pazzi family tries to assasinate Lorenzo and Giuliano de Medici. Lorenzo survives; Giuliano does not. This same year, Leonardo writes in his notebooks that he has begun "two Virgin Marys." He also paints the Portrait of Ginevra de Benci around this time.
1481: ·Leonardo receives a commission to paint the Adoration of the Magi. The painting was never completed, yet was–and is–considered a masterpiece. This same year, most of the other noteworthy painters in Florence were sent to Rome to work on projects for the Pope.
1482: ·Leonardo moves from Florence to Milan, entering the patronage of Ludovico Sforza. By this time, Leonardo is writing in his notebooks regularly.
1483: ·Leonardo receives a commission to paint the Virgin of the Rocks. Also, Raphael is born in 1483.
1485: ·Plague in Milan; Titian born.
1488: ·Verrochio dies.
1489: ·Leonardo studies anatomy.
1490: ·Leonardo begins work in earnest on the bronze horse for his patron Ludovico Sforza. Leonardo begins a book on landscape and hydraulic works; it is never finished. Salai enters his household at the age of 10.
1492: ·Lorenzo de Medici dies; Columbus goes to the New World.
1493: ·A woman named Caterina, possibly Leonardo's mother, possibly a servant, becomes a member of his household in Milan.
1494: ·Savonarola takes power in Florence.
1495: ·Leonardo begins his Last Supper in the convent of Santa Maria delle Grazie.
1496: ·Leonardo illustrates mathematician Fra Luca Pacioli's De divina proportione.
1498: ·Leonardo decorates the walls and ceiling of the Sala delle Asse. He also made his first attempts at planning a flying machine around this time. In 1498, Savonarola is burned at the stake.
1499: ·The French army conquers Milan; Leonardo leaves.
1500: ·Leonardo and Pacioli go to Mantua, then Leonardo continues on to Florence. In Mantua, he draws the Portrait in Profile of Isabelle d'Este. In Florence, he paints the Virgin and Child with Saint Anne.
1502: ·Leonardo becomes Cesare Borgia's military engineer. Leonardo travels around the Romagna, inspecting fortifications. He meets Machiavelli.
1503: ·Back in Florence, Leonardo begins the Battle of Anghiari.Also, in 1503 Florence tries to divert the Arno River away from Pisa in order to defeat Pisa in war. Leonardo and Machiavelli may have cooperated on this project.
1504: ·On July 9, Ser Piero dies.
1505: ·Leonardo makes a second attempt to build a flying machine and begins sketches for the Mona Lisa, which he completes sometime later.In 1505, Leonardo gives up on the Battle of Anghiari, which is deteriorating as he works on it.
1506: ·In May, Leonardo is summoned to Milan by Charles d'Amboise, the French governor.
1507: ·Leonardo is appointed Louis XII's painter and engineer. He paints a second version of the Virgin of the Rocks. He meets his beautiful young assistant, Francesco Melzi. Also, he travels to Florence in a lawsuit against his brothers of his inheritance from his uncle Francesco.
1508: ·Michelangelo begins work on the Sistine Chapel frescoes.
1511: ·Vasari born.
1513: ·Leonardo moves to Rome. Living in the Vatican, he studies the properties of mirrors. It is perhaps at this time that he paints the Turin Self-portrait. It was in this year that Leo X (Medici) became pope; the previous year the Medici family returned to power in Florence.
1515: ·Around this time, Leonardo paints the painting John the Baptist. He also constructs a mechanical lion for the coronation of the new king of France, Francis I.
1516: ·Leonardo permanently leaves Italy for France, where he will serve Francis I in his court in Amboise.
1519: ·In May, Leonardo dies at Cloux.